The raison d'etre of this website is to provide you with hard scientific information which may help you make informed decisions in your quest for health (so far I have blogged concise summaries of over 1,500 scientific studies and have had three books published).

My research is mainly focused on the effects of cholesterol, saturated fat and statin drugs on health. If you know anyone who is worried about their cholesterol levels and heart disease, or has been told to take statin drugs you could send them a link to this website, and to my statin or cholesterol or heart disease books.

David Evans

Independent Health Researcher

Friday, 24 June 2016

Statins significantly reduce dolichol levels

This study was published in BMC Pharmacology and Toxicology 2012, 13(Suppl 1):A51
 
Study title and authors:
Statins reduce endogenous dolichol levels in the neuroblastoma cell line SH-SY5Y
Bihter Atil, Evelyn Sieczkowski and Martin Hohenegger
Institute of Pharmacology, Center for Physiology and Pharmacology, Medical University Vienna, 1090 Vienna, Austria
 
This study can be accessed at: http://www.biomedcentral.com/2050-6511/13/S1/A51


Dolichols play an important role in biosynthesis, protein metabolism, cell vitality and immune system health.


This study assessed the effects of simvastatin on dolichol levels. The laboratory based study used the human SH-SY5Y cells.


The study found that dolichol levels were significantly decreased by simvastatin.


More information about dolichols, statins and the mevalonate pathway:
The deadly effects statins have on the mevalonate pathway
Statin Damage to the Mevalonate Pathway


 

Tuesday, 21 June 2016

Statin use might increase the risk of age-related macular degeneration

This study was published in the Archives of Ophthalmology 2006 Jan;124(1):33-7

Study title and authors:
3-hydroxy-3-methylglutaryl coenzyme a reductase inhibitors and the presence of age-related macular degeneration in the Cardiovascular Health Study.
McGwin G Jr, Modjarrad K, Hall TA, Xie A, Owsley C.
Department of Ophthalmology, School of Medicine, University of Alabama at Birmingham, Suite 609, 700 S. 18th Street, Birmingham, AL 35294-0009, USA. mcgwin@uab.edu

This study can be accessed at: http://www.ncbi.nlm.nih.gov/pubmed/16401782/

The objective of the study was to evaluate both the use of cholesterol-lowering medications as a group and the use of statins specifically with regard to the risk of age-related macular degeneration. The study included 2,755 men and women aged over 65 years.

The study found:
(a) Those taking cholesterol-lowering medications had a 35% increased risk of age-related macular degeneration compared to those not taking cholesterol-lowering medications.
(b) Those taking statins had a 40% increased risk of age-related macular degeneration compared to those not taking statins.

McGwin concluded: "Statin use might increase the risk of age-related macular degeneration".

Sunday, 12 June 2016

Low cholesterol associated with dissociative disorders

This study was published in The American Journal of Psychiatry 2004 Nov;161(11):2121-3


Study title and authors:
Serum lipid levels in patients with dissociative disorder.
Agargun MY, Ozer OA, Kara H, Sekeroglu R, Selvi , Eryonucu B.
Department of Psychiatry, Yüzüncü Yil University School of Medicine, Van 65200, Turkey. myagargun@kure.com.tr

This study can be accessed at: http://www.ncbi.nlm.nih.gov/pubmed/15514416

Someone with a dissociative disorder escapes reality in ways that are involuntary and unhealthy. The person with a dissociative disorder experiences a disconnection and lack of continuity between thoughts, memories, surroundings, actions and identity. Signs and symptoms of dissociative disorders include:
Memory loss (amnesia) of certain time periods, events and people
Mental health problems, such as depression, anxiety, and suicidal thoughts and attempts
A sense of being detached from yourself
A perception of the people and things around you as distorted and unreal
A blurred sense of identity
Significant stress or problems in your relationships, work or other important areas of your life.

This study investigated the association between low cholesterol levels and dissociative disorders. The study included 16 patients with dissociative disorder and 16 normal comparison subjects.

The study found:
(a) Patients with dissociative disorders had 15% lower cholesterol levels than normal comparison subjects.
(b) Patients with dissociative disorders had 27% lower levels of low density lipoprotein (LDL) cholesterol than normal comparison subjects.
(c) Patients with dissociative disorders had 33% lower levels of very low density lipoprotein (VLDL) cholesterol than normal comparison subjects.
(d) Patients with dissociative disorders had 32% lower triglyceride levels than normal comparison subjects.
Agargun concluded: "Low serum lipid concentrations may be related to a high incidence of self-injurious behaviors and borderline features in patients with dissociative disorders."

Links to other studies:
Both low cholesterol levels and declining cholesterol levels are associated with increased risk of death from suicide in men. 
Low cholesterol levels associated with violence, antisocial behaviour and premature death
Low cholesterol increases suicide risk

Friday, 10 June 2016

Statins associated with a 101% increase in diabetes

This study was published in the American Journal of Cardiovascular Drugs 2016 Jun 7


Study title and authors:
Use of Statins and the Risk of Incident Diabetes: A Retrospective Cohort Study.
Olotu BS, Shepherd MD, Novak S, Lawson KA, Wilson JP, Richards KM, Rasu RS.
Department of Pharmacy Practice, University of Kansas School of Pharmacy, 2010 Becker Dr., Lawrence, KS, 66047, USA. buzzlotus@ku.edu.


This study can be accessed at: http://www.ncbi.nlm.nih.gov/pubmed/27272032


The objective of this study was to examine whether the use of statins increases the risk of diabetes. The two year study included 106,424 subjects, aged 20-63 years, of which 53,212 were statin users and 53,212 non statin users. None of the subjects had diabetes at the start of the study.


The study found that statins users had a 101% increased risk of diabetes compared to non users.


Links to other studies: